Tp53 breast cancer

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  inflammatory breast cancer (ibc) is a clinical diagnosis known as the t4d category in the tnm classification. It is a distinct clinical subtype of locally advanced breast cancer (labc), with a particularly aggressive behaviour and poor prognosis. N2 - the tp53 gene (p53) is found altered in breast carcinomas in approximately 20-40 of all cases depending on tumor size and stage of the disease. Tp53 mutations in molecular subtypes of breast and ovarian cancer. Analysis of human tumors through a pan-cancer approach has revealed that various cancers at the molecular level are so different, yet so similarwith substantial intracancer heterogeneity, but also considerable cross-cancer similarities (ciriello et al.).   tp53 is mutated in approximately 30 of breast cancers , but the clinical relevance of mutant status in a tumor is muddled by different studies that show tp53 mutation can be detrimental, neutral, or beneficial to outcome (for examplesreview, see 3,4,5,6). Tp53-mutated breast cancers (bcs) have more elevated expression of hla genes than tp53-wildtype bcs. (a) heatmap shows that tp53-mutated bcs likely more highly express hla genes than tp53-wildtype bcs (metabric). (b) hla genes are more frequently amplified in tp53-mutated bcs than in tp53-wildtype bcs. The tp53 gene (p53) is found altered in breast carcinomas in approximately 2040 of all cases depending on tumor size and stage of the disease. Several polymorphisms in the tp53 gene have been detected and their possible roles in breast cancer risk and association to type of cancer developed are discussed.

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